Alcon ciloxan 0-30 in spanish

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If superinfection occurs, appropriate therapy should be initiated. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. Ciprofloxacin should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity reaction.

Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis. Information For Patients: Do not touch tip to any surface as this may contaminate the ointment. Drug Interactions: Specific drug interaction studies have not been conducted with ophthalmic ciprofloxacin.

However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Carcinogenesis, Mutagenesis, Impairment of Fertility: Eight in vitro mutagenicity tests have been conducted with ciprofloxacin and the test results are listed below:. Thus, two of the eight tests were positive, but the results of the following three in vivo test systems gave negative results:. Long-term carcinogenicity studies in mice and rats have been completed. After daily oral dosing for up to two years, there is no evidence that ciprofloxacin had any carcinogenic or tumorigenic effects in these species.

Pregnancy: Pregnancy Category C. Reproduction studies have been performed in rats and mice at doses up to six times the usual daily human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to ciprofloxacin.

No teratogenicity was observed at either dose. There are no adequate and well controlled studies in pregnant women. Nursing Mothers: It is not known whether topically applied ciprofloxacin is excreted in human milk. However, it is known that orally administered ciprofloxacin is excreted in the milk of lactating rats and oral ciprofloxacin has been reported in human breast milk after a single mg dose. Although ciprofloxacin and other quinolones may cause arthropathy in immature Beagle dogs after oral administration, topical ocular administration of ciprofloxacin to immature animals did not cause any arthropathy and there is no evidence that the ophthalmic dosage form has any effect on the weight bearing joints.

Geriatric Use: No overall clinical differences in safety or effectiveness have been observed between the elderly and other adult patients. Ciprofloxacin and related drugs have been shown to cause arthropathy in immature animals of most species tested following oral administration. However, a one month topical ocular study using immature Beagle dogs did not demonstrate any articular lesions.

Ciloxan Ophthalmic Ointment Alcon. Aerobic gram-positive microorganisms: Staphylococcus aureus methicillin-susceptible strains Staphylococcus epidermidis methicillin-susceptible strains Streptococcus pneumoniae Streptococcus Viridans Group Aerobic gram-negative microorganisms: Haemophilus influenzae The following in vitro data are available; but their clinical significance in ophthalmologic infections is unknown.

Aerobic gram-positive microorganisms: Bacillus species Corynebacterium species Staphylococcus haemolyticus Staphylococcus hominis Aerobic gram-negative microorganisms: Acinetobacter calcoaceticus Enterobacter aerogenes Escherichia coli Haemophilus parainfluenzae Klebsielle pneumoniae Moraxella catarrhalis Neisseria gonorrhoeae Proteus mirabilis Pseudomonas aeruginosa Serratia marcesens Most strains of Burkholderia cepacia and some strains of Stenotrophomonas maltophilia are resistant to ciprofloxacin as are most anaerobic bacteria, including Bacteroides fragilis and Clostridium difficile.

Ophthalmic ointments may retard corneal healing and cause visual blurring. Inactives: sodium acetate, acetic acid, mannitol 4. The pH is approximately 4. The mean concentration was usually less than 2. Microbiology: Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of ciprofloxacin results from interference with the enzyme DNA gyrase which is needed for the synthesis of bacterial DNA.

Ciprofloxacin has been shown to be active in vitro against most strains of the following organisms, however, the clinical significance of these data is unknown :. Other Organisms: Chlamydia trachomatis only moderately susceptible and Mycobacterium tuberculosis only moderately susceptible. Most strains of Pseudomonas cepacia and some strains of Pseudomonas maltophilia are resistant to ciprofloxacin as are most anaerobic bacteria, including Bacteroides fragilis and Clostridium difficile.

The minimal bactericidal concentration MBC generally does not exceed the minimal inhibitory concentration MIC by more than a factor of 2.

Resistance to ciprofloxacin in vitro usually develops slowly multiple-step mutation. Ciprofloxacin does not cross-react with other antimicrobial agents such as beta-lactams or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. CILOXAN Ophthalmic Solution is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions listed below:.

A history of hypersensitivity to ciprofloxacin or any other component of the medication is a contraindication to its use. A history of hypersensitivity to other quinolones may also contraindicate the use of ciprofloxacin. Serious and occasionally fatal hypersensitivity anaphylactic reactions, some following the first dose, have been reported in patients receiving systemic quinolone therapy. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, tingling, pharyngeal or facial edema, dyspnea, urticaria, and itching.

Only a few patients had a history of hypersensitivity reactions. Serious anaphylactic reactions require immediate emergency treatment with epinephrine and other resuscitation measures, including oxygen, intravenous fluids, intravenous antihistamines, corticosteroids, pressor amines and airway management, as clinically indicated. General: As with other antibacterial preparations, prolonged use of ciprofloxacin may result in overgrowth of nonsusceptible organisms, including fungi.